PRDX3
Summary: This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
peroxiredoxin 3 | MIM:604769 | Ensembl:ENSG00000165672 | HGNC:HGNC:9354 | PA33724 | 10q26.11 |
GO terms in PRDX3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0008022 | protein C-terminus binding |
MF | EXP | GO:0008379 | thioredoxin peroxidase activity |
MF | IDA | GO:0008379 | thioredoxin peroxidase activity |
MF | NAS | GO:0008785 | alkyl hydroperoxide reductase activity |
MF | IPI | GO:0019900 | kinase binding |
MF | IPI | GO:0019901 | protein kinase binding |
MF | IPI | GO:0042802 | identical protein binding |
MF | IMP | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005739 | mitochondrion |
CC | TAS | GO:0005759 | mitochondrial matrix |
CC | IDA | GO:0005769 | early endosome |
CC | IDA | GO:0005829 | cytosol |
CC | IPI | GO:0008385 | IkappaB kinase complex |
CC | IDA | GO:0032991 | protein-containing complex |
CC | IEA | GO:0043209 | myelin sheath |
BP | IEA | GO:0001893 | maternal placenta development |
BP | IEA | GO:0006915 | apoptotic process |
BP | IMP | GO:0006979 | response to oxidative stress |
BP | IMP | GO:0007005 | mitochondrion organization |
BP | IDA | GO:0008284 | positive regulation of cell proliferation |
BP | IDA | GO:0018171 | peptidyl-cysteine oxidation |
BP | ISS | GO:0030099 | myeloid cell differentiation |
BP | ISS | GO:0032496 | response to lipopolysaccharide |
BP | IDA | GO:0033673 | negative regulation of kinase activity |
BP | IDA | GO:0034599 | cellular response to oxidative stress |
BP | TAS | GO:0034599 | cellular response to oxidative stress |
BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
BP | IDA | GO:0042542 | response to hydrogen peroxide |
BP | IDA | GO:0042744 | hydrogen peroxide catabolic process |
BP | IMP | GO:0042744 | hydrogen peroxide catabolic process |
BP | IDA | GO:0043066 | negative regulation of apoptotic process |
BP | IMP | GO:0043066 | negative regulation of apoptotic process |
BP | IEA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
BP | IEA | GO:0045454 | cell redox homeostasis |
BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
BP | IMP | GO:0051881 | regulation of mitochondrial membrane potential |
BP | IEA | GO:0098869 | cellular oxidant detoxification |
Gene expression in normal tissue: PRDX3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRDX3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-2262752 | Cellular responses to stress |
reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
reactome | R-HSA-8953897 | Cellular responses to external stimuli |
wikipathways | WP15 | Selenium Micronutrient Network |
pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRDX3