Summary: This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014].

peroxiredoxin 3MIM:604769Ensembl:ENSG00000165672HGNC:HGNC:9354PA3372410q26.11

GO terms in PRDX3

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFEXPGO:0008379thioredoxin peroxidase activity
MFIDAGO:0008379thioredoxin peroxidase activity
MFNASGO:0008785alkyl hydroperoxide reductase activity
MFIPIGO:0019900kinase binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0042802identical protein binding
MFIMPGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
CCTASGO:0005759mitochondrial matrix
CCIDAGO:0005769early endosome
CCIPIGO:0008385IkappaB kinase complex
CCIDAGO:0032991protein-containing complex
CCIEAGO:0043209myelin sheath
BPIEAGO:0001893maternal placenta development
BPIEAGO:0006915apoptotic process
BPIMPGO:0006979response to oxidative stress
BPIMPGO:0007005mitochondrion organization
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0018171peptidyl-cysteine oxidation
BPISSGO:0030099myeloid cell differentiation
BPISSGO:0032496response to lipopolysaccharide
BPIDAGO:0033673negative regulation of kinase activity
BPIDAGO:0034599cellular response to oxidative stress
BPTASGO:0034599cellular response to oxidative stress
BPIMPGO:0034614cellular response to reactive oxygen species
BPIDAGO:0042542response to hydrogen peroxide
BPIDAGO:0042744hydrogen peroxide catabolic process
BPIMPGO:0042744hydrogen peroxide catabolic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPIEAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0045454cell redox homeostasis
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0051881regulation of mitochondrial membrane potential
BPIEAGO:0098869cellular oxidant detoxification

Gene expression in normal tissue: PRDX3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDX3

DatabasePathway IDPathway Des.
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3299685Detoxification of Reactive Oxygen Species
reactomeR-HSA-8953897Cellular responses to external stimuli
wikipathwaysWP15Selenium Micronutrient Network
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDX3