PREPL


Summary: The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
prolyl endopeptidase likeMIM:609557Ensembl:ENSG00000138078HGNC:HGNC:30228PA1426711342p21

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in PREPL


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004252serine-type endopeptidase activity
MFIEAGO:0070008serine-type exopeptidase activity
BPIEAGO:0006508proteolysis
BPIMPGO:2000300regulation of synaptic vesicle exocytosis
CCIBAGO:0005794Golgi apparatus
CCIEAGO:0005829cytosol
CCIBAGO:0005856cytoskeleton

Gene expression in normal tissue: PREPL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PREPL


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PREPL

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