PTGR1
Summary: This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prostaglandin reductase 1 | MIM:601274 | Ensembl:ENSG00000106853 | HGNC:HGNC:18429 | PA162400322 | 9q31.3 |
GO terms in PTGR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | NAS | GO:0006691 | leukotriene metabolic process |
| BP | IEA | GO:0006693 | prostaglandin metabolic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0097327 | response to antineoplastic agent |
| MF | IEA | GO:0032440 | 2-alkenal reductase [NAD(P)] activity |
| MF | IEA | GO:0036132 | 13-prostaglandin reductase activity |
| MF | IEA | GO:0047522 | 15-oxoprostaglandin 13-oxidase activity |
Gene expression in normal tissue: PTGR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTGR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
| reactome | R-HSA-2142700 | Synthesis of Lipoxins (LX) |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTGR1
CLASSFICATION
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