PTGR1


Summary: This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
prostaglandin reductase 1MIM:601274Ensembl:ENSG00000106853HGNC:HGNC:18429PA1624003229q31.3

GO terms in PTGR1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005737cytoplasm
CCHDAGO:0070062extracellular exosome
BPNASGO:0006691leukotriene metabolic process
BPIEAGO:0006693prostaglandin metabolic process
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0097327response to antineoplastic agent
MFIEAGO:00324402-alkenal reductase [NAD(P)] activity
MFIEAGO:003613213-prostaglandin reductase activity
MFIEAGO:004752215-oxoprostaglandin 13-oxidase activity

Gene expression in normal tissue: PTGR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTGR1


DatabasePathway IDPathway Des.
humancycPWY3DJ-11470sphingosine and sphingosine-1-phosphate metabolism
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)
reactomeR-HSA-2142700Synthesis of Lipoxins (LX)
reactomeR-HSA-2142753Arachidonic acid metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8978868Fatty acid metabolism
reactomeR-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTGR1

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