PTP4A3
Summary: This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase type IVA, member 3 | MIM:606449 | Ensembl:ENSG00000184489 | HGNC:HGNC:9636 | PA33979 | 8q24.3 |
GO terms in PTP4A3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0004727 | prenylated protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IEA | GO:0043117 | positive regulation of vascular permeability |
| BP | IBA | GO:0043542 | endothelial cell migration |
| BP | IMP | GO:0043542 | endothelial cell migration |
| BP | IEA | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1904951 | positive regulation of establishment of protein localization |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | IBA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005769 | early endosome |
| CC | IEA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: PTP4A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTP4A3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTP4A3
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