Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].

protein tyrosine phosphatase, non-receptor type 12MIM:600079Ensembl:ENSG00000127947HGNC:HGNC:9645PA339877q11.23

GO terms in PTPN12

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006470protein dephosphorylation
BPIDAGO:0035335peptidyl-tyrosine dephosphorylation
BPTASGO:0038128ERBB2 signaling pathway
BPIMPGO:0042058regulation of epidermal growth factor receptor signaling pathway
BPIEAGO:0042246tissue regeneration
BPTASGO:0071345cellular response to cytokine stimulus
BPIMPGO:0071364cellular response to epidermal growth factor stimulus
BPTASGO:1901185negative regulation of ERBB signaling pathway
BPTASGO:2000587negative regulation of platelet-derived growth factor receptor-beta signaling pathway
CCIEAGO:0005925focal adhesion
CCIEAGO:0042995cell projection
MFIDAGO:0004721phosphoprotein phosphatase activity
MFEXPGO:0004725protein tyrosine phosphatase activity
MFTASGO:0004726non-membrane spanning protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIPIGO:0017124SH3 domain binding

Gene expression in normal tissue: PTPN12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPN12

DatabasePathway IDPathway Des.
wikipathwaysWP437EGF-EGFR Signaling Pathway
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-8863795Downregulation of ERBB2 signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9008059Interleukin-37 signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPN12