PTPRB


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein tyrosine phosphatase, receptor type BMIM:176882Ensembl:ENSG00000127329HGNC:HGNC:9665PA3401012q15

GO terms in PTPRB


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005001transmembrane receptor protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0035579specific granule membrane
CCIDAGO:0043235receptor complex
CCTASGO:0070821tertiary granule membrane
BPIEAGO:0001525angiogenesis
BPTASGO:0006470protein dephosphorylation
BPTASGO:0006796phosphate-containing compound metabolic process
BPIDAGO:0016311dephosphorylation
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
BPTASGO:0043312neutrophil degranulation

Gene expression in normal tissue: PTPRB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRB


DatabasePathway IDPathway Des.
biocartasprypathwaysprouty regulation of tyrosine kinase signals
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation
wikipathwaysWP2858Ectoderm Differentiation
kegghsa04520Adherens junction - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD241Sunitinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRB

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