PTPRK
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type K | MIM:602545 | Ensembl:ENSG00000152894 | HGNC:HGNC:9674 | PA34019 | 6q22.33 |
GO terms in PTPRK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | NAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0045295 | gamma-catenin binding |
| CC | IEA | GO:0001750 | photoreceptor outer segment |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0005912 | adherens junction |
| CC | IDA | GO:0009986 | cell surface |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0030054 | cell junction |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0031256 | leading edge membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | IMP | GO:0007155 | cell adhesion |
| BP | IDA | GO:0007165 | signal transduction |
| BP | IDA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0010839 | negative regulation of keratinocyte proliferation |
| BP | IMP | GO:0016477 | cell migration |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0031175 | neuron projection development |
| BP | IDA | GO:0034394 | protein localization to cell surface |
| BP | IDA | GO:0034614 | cellular response to reactive oxygen species |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0048041 | focal adhesion assembly |
Gene expression in normal tissue: PTPRK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRK
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