PTPRN2
Summary: This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type N2 | MIM:601698 | Ensembl:ENSG00000155093 | HGNC:HGNC:9677 | PA34022 | 7q36.3 |
GO terms in PTPRN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0006629 | lipid metabolic process |
| BP | ISS | GO:0007269 | neurotransmitter secretion |
| BP | IEA | GO:0034260 | negative regulation of GTPase activity |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | ISS | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | IEA | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030667 | secretory granule membrane |
| CC | ISS | GO:0030672 | synaptic vesicle membrane |
| CC | IEA | GO:0043195 | terminal bouton |
| CC | IDA | GO:0043235 | receptor complex |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
Gene expression in normal tissue: PTPRN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRN2
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