QARS
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutaminyl-tRNA synthetase | MIM:603727 | Ensembl:ENSG00000172053 | HGNC:HGNC:9751 | PA34093 | 3p21.31 |
GO terms in QARS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004819 | glutamine-tRNA ligase activity |
| MF | IDA | GO:0004819 | glutamine-tRNA ligase activity |
| MF | TAS | GO:0004819 | glutamine-tRNA ligase activity |
| MF | IMP | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| BP | TAS | GO:0006418 | tRNA aminoacylation for protein translation |
| BP | IBA | GO:0006425 | glutaminyl-tRNA aminoacylation |
| BP | IDA | GO:0006425 | glutaminyl-tRNA aminoacylation |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IMP | GO:0007420 | brain development |
| BP | IDA | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:2001234 | negative regulation of apoptotic signaling pathway |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: QARS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in QARS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00072 | Glutamate Metabolism |
| smpdb | SMP00136 | 2-Hydroxyglutric Aciduria (D And L Form) |
| smpdb | SMP00243 | 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency |
| smpdb | SMP00339 | Hyperinsulinism-Hyperammonemia Syndrome |
| smpdb | SMP00385 | Homocarnosinosis |
| smpdb | SMP00567 | Succinic semialdehyde dehydrogenase deficiency |
| humancyc | TRNA-CHARGING-PWY | tRNA charging |
| kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2408517 | SeMet incorporation into proteins |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-379716 | Cytosolic tRNA aminoacylation |
| reactome | R-HSA-379724 | tRNA Aminoacylation |
| reactome | R-HSA-379726 | Mitochondrial tRNA aminoacylation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-72766 | Translation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in QARS
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