QSOX1
Summary: This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| quiescin sulfhydryl oxidase 1 | MIM:603120 | Ensembl:ENSG00000116260 | HGNC:HGNC:9756 | PA162400559 | 1q25.2 |
GO terms in QSOX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IBA | GO:0006457 | protein folding |
| BP | IMP | GO:0016242 | negative regulation of macroautophagy |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0030173 | integral component of Golgi membrane |
| CC | IDA | GO:0030173 | integral component of Golgi membrane |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| MF | IBA | GO:0003756 | protein disulfide isomerase activity |
| MF | IDA | GO:0003756 | protein disulfide isomerase activity |
| MF | IBA | GO:0016971 | flavin-linked sulfhydryl oxidase activity |
| MF | IDA | GO:0016971 | flavin-linked sulfhydryl oxidase activity |
Gene expression in normal tissue: QSOX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in QSOX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in QSOX1
CLASSFICATION
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