RARA
Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| retinoic acid receptor alpha | MIM:180240 | Ensembl:ENSG00000131759 | HGNC:HGNC:9864 | PA34225 | 17q21.2 |
GO terms in RARA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001657 | ureteric bud development |
| BP | IEA | GO:0001843 | neural tube closure |
| BP | IBA | GO:0001889 | liver development |
| BP | IEA | GO:0001889 | liver development |
| BP | IEA | GO:0002068 | glandular epithelial cell development |
| BP | IEA | GO:0003148 | outflow tract septum morphogenesis |
| BP | IEA | GO:0003417 | growth plate cartilage development |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007281 | germ cell development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0007420 | brain development |
| BP | IBA | GO:0007507 | heart development |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030850 | prostate gland development |
| BP | IDA | GO:0030853 | negative regulation of granulocyte differentiation |
| BP | IBA | GO:0030855 | epithelial cell differentiation |
| BP | IEA | GO:0031076 | embryonic camera-type eye development |
| BP | IEA | GO:0031641 | regulation of myelination |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IBA | GO:0032526 | response to retinoic acid |
| BP | IMP | GO:0032526 | response to retinoic acid |
| BP | IDA | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IDA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0032736 | positive regulation of interleukin-13 production |
| BP | IDA | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IDA | GO:0032754 | positive regulation of interleukin-5 production |
| BP | IEA | GO:0033189 | response to vitamin A |
| BP | IBA | GO:0033993 | response to lipid |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043277 | apoptotic cell clearance |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IDA | GO:0045630 | positive regulation of T-helper 2 cell differentiation |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IMP | GO:0045787 | positive regulation of cell cycle |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045947 | negative regulation of translational initiation |
| BP | IEA | GO:0048167 | regulation of synaptic plasticity |
| BP | IBA | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IMP | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IBA | GO:0048568 | embryonic organ development |
| BP | IBA | GO:0048732 | gland development |
| BP | IMP | GO:0051099 | positive regulation of binding |
| BP | IEA | GO:0055012 | ventricular cardiac muscle cell differentiation |
| BP | IEA | GO:0060010 | Sertoli cell fate commitment |
| BP | IEA | GO:0060173 | limb development |
| BP | IEA | GO:0060324 | face development |
| BP | IBA | GO:0060349 | bone morphogenesis |
| BP | IBA | GO:0060429 | epithelium development |
| BP | IEA | GO:0060534 | trachea cartilage development |
| BP | IEA | GO:0060591 | chondroblast differentiation |
| BP | IEA | GO:0061037 | negative regulation of cartilage development |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IBA | GO:0071300 | cellular response to retinoic acid |
| BP | IDA | GO:0071300 | cellular response to retinoic acid |
| BP | IDA | GO:0071391 | cellular response to estrogen stimulus |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IC | GO:0009986 | cell surface |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IBA | GO:0090575 | RNA polymerase II transcription factor complex |
| MF | IEA | GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IDA | GO:0001972 | retinoic acid binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IBA | GO:0003708 | retinoic acid receptor activity |
| MF | IDA | GO:0003708 | retinoic acid receptor activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IBA | GO:0004879 | nuclear receptor activity |
| MF | IDA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0031490 | chromatin DNA binding |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | IPI | GO:0043422 | protein kinase B binding |
| MF | IDA | GO:0044323 | retinoic acid-responsive element binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0048027 | mRNA 5'-UTR binding |
| MF | IDA | GO:0051018 | protein kinase A binding |
| MF | IPI | GO:0051393 | alpha-actinin binding |
| MF | IBA | GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Gene expression in normal tissue: RARA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RARA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | rarpathway | degradation of the rar and rxr by the proteasome |
| biocarta | rarrxrpathway | nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP716 | Vitamin A and Carotenoid Metabolism |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD366 | PI-103 | 13 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 9 |
| iGMDRD286 | Nsc 632839 | 10 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD255 | SB225002 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RARA
CLASSFICATION
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