RASGRP1
Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAS guanyl releasing protein 1 | MIM:603962 | Ensembl:ENSG00000172575 | HGNC:HGNC:9878 | PA34240 | 15q14 |
GO terms in RASGRP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001816 | cytokine production |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0032252 | secretory granule localization |
| BP | IMP | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production |
| BP | IMP | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IEA | GO:0032825 | positive regulation of natural killer cell differentiation |
| BP | IEA | GO:0033089 | positive regulation of T cell differentiation in thymus |
| BP | IEA | GO:0043303 | mast cell degranulation |
| BP | IMP | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | IMP | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | IEA | GO:0047496 | vesicle transport along microtubule |
| BP | IMP | GO:0051259 | protein complex oligomerization |
| BP | IMP | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0090630 | activation of GTPase activity |
| BP | IMP | GO:0090630 | activation of GTPase activity |
| BP | IMP | GO:1900274 | regulation of phospholipase C activity |
| BP | IMP | GO:1900744 | regulation of p38MAPK cascade |
| BP | IMP | GO:1902715 | positive regulation of interferon-gamma secretion |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0042629 | mast cell granule |
| MF | IMP | GO:0001786 | phosphatidylserine binding |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IMP | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005096 | GTPase activator activity |
| MF | IMP | GO:0005509 | calcium ion binding |
| MF | IMP | GO:0008270 | zinc ion binding |
| MF | TAS | GO:0008289 | lipid binding |
| MF | IMP | GO:0019992 | diacylglycerol binding |
| MF | IMP | GO:0031210 | phosphatidylcholine binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: RASGRP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RASGRP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP732 | Serotonin Receptor 2 and ELK-SRF-GATA4 signaling |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169092 | Activation of RAS in B cells |
| reactome | R-HSA-1169092 | Activation of RAS in B cells |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392517 | Rap1 signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RASGRP1
CLASSFICATION
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