RBBP4


Summary: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RB binding protein 4, chromatin remodeling factorMIM:602923Ensembl:ENSG00000162521HGNC:HGNC:9887PA342511p35.1

GO terms in RBBP4


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFHDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFTASGO:0004407histone deacetylase activity
MFIPIGO:0005515protein binding
MFIDAGO:0008094DNA-dependent ATPase activity
MFHDAGO:0031492nucleosomal DNA binding
MFNASGO:0042393histone binding
MFIPIGO:0042826histone deacetylase binding
BPIEAGO:0006260DNA replication
BPIDAGO:0006335DNA replication-dependent nucleosome assembly
BPIDAGO:0006336DNA replication-independent nucleosome assembly
BPIDAGO:0006338chromatin remodeling
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0007049cell cycle
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0016575histone deacetylation
BPIDAGO:0031497chromatin assembly
BPTASGO:0034080CENP-A containing nucleosome assembly
BPHDAGO:0043044ATP-dependent chromatin remodeling
BPTASGO:0045814negative regulation of gene expression, epigenetic
BPTASGO:0051726regulation of cell cycle
BPIEAGO:0060416response to growth hormone
BPTASGO:0070317negative regulation of G0 to G1 transition
CCHDAGO:0000790nuclear chromatin
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCNASGO:0016580Sin3 complex
CCIDAGO:0016581NuRD complex
CCNASGO:0016581NuRD complex
CCIDAGO:0016589NURF complex
CCHDAGO:0032991protein-containing complex
CCIDAGO:0032991protein-containing complex
CCIDAGO:0033186CAF-1 complex
CCIDAGO:0035098ESC/E(Z) complex

Gene expression in normal tissue: RBBP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RBBP4


DatabasePathway IDPathway Des.
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2916Interactome of polycomb repressive complex 2 (PRC2)
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
wikipathwaysWP4239EMT transition in Colorectal Cancer
pide2f_pathwayE2F transcription factor network
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidrb_1pathwayRegulation of retinoblastoma protein
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
pidtelomerasepathwayRegulation of Telomerase
kegghsa04218Cellular senescence - Homo sapiens (human)
biocartaprc2pathwaythe prc2 complex sets long-term gene silencing through modification of histone tails
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-156711Polo-like kinase mediated events
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-212300PRC2 methylates histones and DNA
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-3214815HDACs deacetylate histones
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5250913Positive epigenetic regulation of rRNA expression
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromere
reactomeR-HSA-6804758Regulation of TP53 Activity through Acetylation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69242S Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73762RNA Polymerase I Transcription Initiation
reactomeR-HSA-73854RNA Polymerase I Promoter Clearance
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73864RNA Polymerase I Transcription
reactomeR-HSA-73886Chromosome Maintenance
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-774815Nucleosome assembly
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8953750Transcriptional Regulation by E2F6
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RBBP4

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