RBBP4
Summary: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RB binding protein 4, chromatin remodeling factor | MIM:602923 | Ensembl:ENSG00000162521 | HGNC:HGNC:9887 | PA34251 | 1p35.1 |
GO terms in RBBP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | HDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| MF | HDA | GO:0031492 | nucleosomal DNA binding |
| MF | NAS | GO:0042393 | histone binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| BP | IEA | GO:0006260 | DNA replication |
| BP | IDA | GO:0006335 | DNA replication-dependent nucleosome assembly |
| BP | IDA | GO:0006336 | DNA replication-independent nucleosome assembly |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0016575 | histone deacetylation |
| BP | IDA | GO:0031497 | chromatin assembly |
| BP | TAS | GO:0034080 | CENP-A containing nucleosome assembly |
| BP | HDA | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | TAS | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0060416 | response to growth hormone |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| CC | HDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | NAS | GO:0016580 | Sin3 complex |
| CC | IDA | GO:0016581 | NuRD complex |
| CC | NAS | GO:0016581 | NuRD complex |
| CC | IDA | GO:0016589 | NURF complex |
| CC | HDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0033186 | CAF-1 complex |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
Gene expression in normal tissue: RBBP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBBP4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | telomerasepathway | Regulation of Telomerase |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212300 | PRC2 methylates histones and DNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere |
| reactome | R-HSA-6804758 | Regulation of TP53 Activity through Acetylation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-774815 | Nucleosome assembly |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBBP4
CLASSFICATION
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