RBMS3
Summary: This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RNA binding motif single stranded interacting protein 3 | MIM:605786 | Ensembl:ENSG00000144642 | HGNC:HGNC:13427 | PA34276 | 3p24.1 |
GO terms in RBMS3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0002357 | defense response to tumor cell |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0045727 | positive regulation of translation |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IBA | GO:0008143 | poly(A) binding |
| MF | IDA | GO:0008143 | poly(A) binding |
| MF | IBA | GO:0008266 | poly(U) RNA binding |
| MF | IDA | GO:0008266 | poly(U) RNA binding |
| MF | IDA | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
Gene expression in normal tissue: RBMS3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBMS3
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBMS3
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