Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

regulator of G protein signaling 18MIM:607192Ensembl:ENSG00000150681HGNC:HGNC:14261PA343691q31.2

GO terms in RGS18

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0008277regulation of G-protein coupled receptor protein signaling pathway
BPIEAGO:0009968negative regulation of signal transduction
BPIEAGO:0043547positive regulation of GTPase activity

Gene expression in normal tissue: RGS18

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RGS18

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP536Calcium Regulation in the Cardiac Cell

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RGS18