RHOG


Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ras homolog family member GMIM:179505Ensembl:ENSG00000177105HGNC:HGNC:672PA2495511p15.4

GO terms in RHOG


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005829cytosol
CCIBAGO:0005856cytoskeleton
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIBAGO:0005938cell cortex
CCTASGO:0030667secretory granule membrane
CCIBAGO:0031410cytoplasmic vesicle
CCIBAGO:0031982vesicle
CCIBAGO:0042995cell projection
CCIBAGO:0043231intracellular membrane-bounded organelle
CCHDAGO:0070062extracellular exosome
BPIBAGO:0007015actin filament organization
BPIBAGO:0007163establishment or maintenance of cell polarity
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007266Rho protein signal transduction
BPIDAGO:0007266Rho protein signal transduction
BPTASGO:0008284positive regulation of cell proliferation
BPIBAGO:0008360regulation of cell shape
BPIDAGO:0016601Rac protein signal transduction
BPIBAGO:0030036actin cytoskeleton organization
BPIDAGO:0030036actin cytoskeleton organization
BPIBAGO:0030865cortical cytoskeleton organization
BPIBAGO:0032956regulation of actin cytoskeleton organization
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0043652engulfment of apoptotic cell
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIMPGO:0060326cell chemotaxis
BPIMPGO:0090630activation of GTPase activity
BPIEAGO:1900027regulation of ruffle assembly
BPIMPGO:1903078positive regulation of protein localization to plasma membrane
MFIBAGO:0003924GTPase activity
MFIDAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005525GTP binding
MFIEAGO:0005525GTP binding
MFIBAGO:0019901protein kinase binding

Gene expression in normal tissue: RHOG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RHOG


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-5625970RHO GTPases activate KTN1
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-76002Platelet activation, signaling and aggregation
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
pidilk_pathwayIntegrin-linked kinase signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RHOG

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