RHOG
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ras homolog family member G | MIM:179505 | Ensembl:ENSG00000177105 | HGNC:HGNC:672 | PA24955 | 11p15.4 |
GO terms in RHOG
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
CC | TAS | GO:0005829 | cytosol |
CC | IBA | GO:0005856 | cytoskeleton |
CC | IBA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | HDA | GO:0005925 | focal adhesion |
CC | IBA | GO:0005938 | cell cortex |
CC | TAS | GO:0030667 | secretory granule membrane |
CC | IBA | GO:0031410 | cytoplasmic vesicle |
CC | IBA | GO:0031982 | vesicle |
CC | IBA | GO:0042995 | cell projection |
CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
CC | HDA | GO:0070062 | extracellular exosome |
BP | IBA | GO:0007015 | actin filament organization |
BP | IBA | GO:0007163 | establishment or maintenance of cell polarity |
BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
BP | IBA | GO:0007266 | Rho protein signal transduction |
BP | IDA | GO:0007266 | Rho protein signal transduction |
BP | TAS | GO:0008284 | positive regulation of cell proliferation |
BP | IBA | GO:0008360 | regulation of cell shape |
BP | IDA | GO:0016601 | Rac protein signal transduction |
BP | IBA | GO:0030036 | actin cytoskeleton organization |
BP | IDA | GO:0030036 | actin cytoskeleton organization |
BP | IBA | GO:0030865 | cortical cytoskeleton organization |
BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
BP | TAS | GO:0043312 | neutrophil degranulation |
BP | IBA | GO:0043652 | engulfment of apoptotic cell |
BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
BP | IMP | GO:0060326 | cell chemotaxis |
BP | IMP | GO:0090630 | activation of GTPase activity |
BP | IEA | GO:1900027 | regulation of ruffle assembly |
BP | IMP | GO:1903078 | positive regulation of protein localization to plasma membrane |
MF | IBA | GO:0003924 | GTPase activity |
MF | IDA | GO:0003924 | GTPase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0005525 | GTP binding |
MF | IEA | GO:0005525 | GTP binding |
MF | IBA | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: RHOG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHOG
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-114604 | GPVI-mediated activation cascade |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
reactome | R-HSA-194840 | Rho GTPase cycle |
reactome | R-HSA-195258 | RHO GTPase Effectors |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-388396 | GPCR downstream signalling |
reactome | R-HSA-416482 | G alpha (12/13) signalling events |
reactome | R-HSA-5625970 | RHO GTPases activate KTN1 |
reactome | R-HSA-6798695 | Neutrophil degranulation |
reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
pid | ilk_pathway | Integrin-linked kinase signaling |
pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHOG