RIN3


Summary: Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Ras and Rab interactor 3MIM:610223Ensembl:ENSG00000100599HGNC:HGNC:18751PA3867314q32.12

GO terms in RIN3


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIMPGO:0017112Rab guanyl-nucleotide exchange factor activity
MFTASGO:0017112Rab guanyl-nucleotide exchange factor activity
MFIDAGO:0017137Rab GTPase binding
CCIDAGO:0005769early endosome
CCTASGO:0005829cytosol
CCIDAGO:0031410cytoplasmic vesicle
BPNASGO:0006897endocytosis
BPIEAGO:0007165signal transduction
BPIEAGO:0043547positive regulation of GTPase activity

Gene expression in normal tissue: RIN3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIN3


DatabasePathway IDPathway Des.
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8876198RAB GEFs exchange GTP for GDP on RABs
reactomeR-HSA-9007101Rab regulation of trafficking

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIN3

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