RNASE2
Summary: The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonuclease A family member 2 | MIM:131410 | Ensembl:ENSG00000169385 | HGNC:HGNC:10045 | PA34413 | 14q11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RNASE2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0001530 | lipopolysaccharide binding |
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0004519 | endonuclease activity |
| MF | IEA | GO:0004522 | ribonuclease A activity |
| MF | IBA | GO:0004540 | ribonuclease activity |
| MF | IDA | GO:0004540 | ribonuclease activity |
| BP | TAS | GO:0006401 | RNA catabolic process |
| BP | IDA | GO:0006935 | chemotaxis |
| BP | IMP | GO:0043152 | induction of bacterial agglutination |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IMP | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | IDA | GO:0090501 | RNA phosphodiester bond hydrolysis |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RNASE2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASE2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASE2
CLASSFICATION
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