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RNASEH2B

Summary: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ribonuclease H2 subunit B	MIM:610326	Ensembl:ENSG00000136104	HGNC:HGNC:25671	PA162401418	13q14.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in RNASEH2B

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004523	RNA-DNA hybrid ribonuclease activity
BP	IEA	GO:0001701	in utero embryonic development
BP	IDA	GO:0006401	RNA catabolic process
BP	IEA	GO:0009259	ribonucleotide metabolic process
BP	IEA	GO:0010389	regulation of G2/M transition of mitotic cell cycle
BP	IEA	GO:0010629	negative regulation of gene expression
BP	IEA	GO:0048146	positive regulation of fibroblast proliferation
BP	IEA	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
BP	IEA	GO:2000001	regulation of DNA damage checkpoint
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0032299	ribonuclease H2 complex

Gene expression in normal tissue: RNASEH2B

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RNASEH2B

Database	Pathway ID	Pathway Des.
kegg	hsa03030	DNA replication - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASEH2B

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DATATYPES

CLASSFICATION

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