RNASEH2B
Summary: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ribonuclease H2 subunit B | MIM:610326 | Ensembl:ENSG00000136104 | HGNC:HGNC:25671 | PA162401418 | 13q14.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in RNASEH2B
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
BP | IEA | GO:0001701 | in utero embryonic development |
BP | IDA | GO:0006401 | RNA catabolic process |
BP | IEA | GO:0009259 | ribonucleotide metabolic process |
BP | IEA | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
BP | IEA | GO:0010629 | negative regulation of gene expression |
BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
BP | IEA | GO:2000001 | regulation of DNA damage checkpoint |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0032299 | ribonuclease H2 complex |
Gene expression in normal tissue: RNASEH2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASEH2B
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa03030 | DNA replication - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASEH2B