RNASET2
Summary: This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ribonuclease T2 | MIM:612944 | Ensembl:ENSG00000026297 | HGNC:HGNC:21686 | PA128394541 | 6q27 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RNASET2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003723 | RNA binding |
MF | IBA | GO:0004521 | endoribonuclease activity |
MF | IDA | GO:0004540 | ribonuclease activity |
MF | IEA | GO:0033897 | ribonuclease T2 activity |
BP | IBA | GO:0006401 | RNA catabolic process |
BP | IDA | GO:0006401 | RNA catabolic process |
BP | TAS | GO:0043312 | neutrophil degranulation |
BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
CC | IBA | GO:0005576 | extracellular region |
CC | TAS | GO:0005576 | extracellular region |
CC | HDA | GO:0005615 | extracellular space |
CC | IDA | GO:0005615 | extracellular space |
CC | IDA | GO:0005764 | lysosome |
CC | IDA | GO:0005788 | endoplasmic reticulum lumen |
CC | TAS | GO:0035578 | azurophil granule lumen |
CC | IEA | GO:0043202 | lysosomal lumen |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RNASET2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASET2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASET2