RNASET2


Summary: This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribonuclease T2MIM:612944Ensembl:ENSG00000026297HGNC:HGNC:21686PA1283945416q27

Gene Categories:

DRUGGABLE GENOME

GO terms in RNASET2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003723RNA binding
MFIBAGO:0004521endoribonuclease activity
MFIDAGO:0004540ribonuclease activity
MFIEAGO:0033897ribonuclease T2 activity
BPIBAGO:0006401RNA catabolic process
BPIDAGO:0006401RNA catabolic process
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic
CCIBAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0005764lysosome
CCIDAGO:0005788endoplasmic reticulum lumen
CCTASGO:0035578azurophil granule lumen
CCIEAGO:0043202lysosomal lumen
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: RNASET2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RNASET2


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASET2

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