RPA2


Summary: This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
replication protein A2MIM:179836Ensembl:ENSG00000117748HGNC:HGNC:10290PA346521p35.3

GO terms in RPA2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPICGO:0000723telomere maintenance
BPIMPGO:0000723telomere maintenance
BPIMPGO:0000724double-strand break repair via homologous recombination
BPIDAGO:0006260DNA replication
BPIMPGO:0006260DNA replication
BPTASGO:0006260DNA replication
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPIDAGO:0006284base-excision repair
BPIMPGO:0006289nucleotide-excision repair
BPTASGO:0006293nucleotide-excision repair, preincision complex stabilization
BPTASGO:0006294nucleotide-excision repair, preincision complex assembly
BPTASGO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion
BPTASGO:0006297nucleotide-excision repair, DNA gap filling
BPIMPGO:0006298mismatch repair
BPIMPGO:0010569regulation of double-strand break repair via homologous recombination
BPTASGO:0019985translesion synthesis
BPIMPGO:0031571mitotic G1 DNA damage checkpoint
BPTASGO:0032201telomere maintenance via semi-conservative replication
BPTASGO:0033683nucleotide-excision repair, DNA incision
BPIDAGO:0034502protein localization to chromosome
BPTASGO:0036297interstrand cross-link repair
BPTASGO:0042276error-prone translesion synthesis
BPTASGO:0042769DNA damage response, detection of DNA damage
BPTASGO:0070987error-free translesion synthesis
BPTASGO:1900034regulation of cellular response to heat
BPIMPGO:2000001regulation of DNA damage checkpoint
CCIDAGO:0000781chromosome, telomeric region
CCHDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000785chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005662DNA replication factor A complex
CCIPIGO:0005662DNA replication factor A complex
CCIDAGO:0016604nuclear body
CCIDAGO:0016605PML body
CCIDAGO:0016605PML body
CCIDAGO:0035861site of double-strand break
MFIBAGO:0003684damaged DNA binding
MFIDAGO:0003684damaged DNA binding
MFIBAGO:0003690double-stranded DNA binding
MFIBAGO:0003697single-stranded DNA binding
MFICGO:0003697single-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFISSGO:0003697single-stranded DNA binding
MFIBAGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019903protein phosphatase binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIBAGO:0043565sequence-specific DNA binding
MFIEAGO:0047485protein N-terminus binding
MFIBAGO:0098505G-rich strand telomeric DNA binding
MFIDAGO:0098505G-rich strand telomeric DNA binding

Gene expression in normal tissue: RPA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPA2


DatabasePathway IDPathway Des.
reactomeR-HSA-110312Translesion synthesis by REV1
reactomeR-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
reactomeR-HSA-110314Recognition of DNA damage by PCNA-containing replication complex
reactomeR-HSA-110320Translesion Synthesis by POLH
reactomeR-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathway
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-157579Telomere Maintenance
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174414Processive synthesis on the C-strand of the telomere
reactomeR-HSA-174417Telomere C-strand (Lagging Strand) Synthesis
reactomeR-HSA-174437Removal of the Flap Intermediate from the C-strand
reactomeR-HSA-176187Activation of ATR in response to replication stress
reactomeR-HSA-180786Extension of Telomeres
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371511HSF1 activation
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-5358508Mismatch Repair
reactomeR-HSA-5358508Mismatch Repair
reactomeR-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
reactomeR-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
reactomeR-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5651801PCNA-Dependent Long Patch Base Excision Repair
reactomeR-HSA-5655862Translesion synthesis by POLK
reactomeR-HSA-5656121Translesion synthesis by POLI
reactomeR-HSA-5656169Termination of translesion DNA synthesis
reactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-5696395Formation of Incision Complex in GG-NER
reactomeR-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-5696400Dual Incision in GG-NER
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-6783310Fanconi Anemia Pathway
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69166Removal of the Flap Intermediate
reactomeR-HSA-69183Processive synthesis on the lagging strand
reactomeR-HSA-69186Lagging Strand Synthesis
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73884Base Excision Repair
reactomeR-HSA-73886Chromosome Maintenance
reactomeR-HSA-73893DNA Damage Bypass
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73933Resolution of Abasic Sites (AP sites)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-912446Meiotic recombination
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP466DNA Replication
wikipathwaysWP707DNA Damage Response
kegghsa03030DNA replication - Homo sapiens (human)
kegghsa03420Nucleotide excision repair - Homo sapiens (human)
kegghsa03430Mismatch repair - Homo sapiens (human)
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)
pidatr_pathwayATR signaling pathway
pidfanconi_pathwayFanconi anemia pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD264Bryostatin 11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPA2

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