Summary: This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008].

ribosomal protein S27 likeMIM:612055Ensembl:ENSG00000185088HGNC:HGNC:18476PA3854615q22.2

GO terms in RPS27L

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003735structural constituent of ribosome
MFIPIGO:0005515protein binding
MFIDAGO:0008494translation activator activity
MFIDAGO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process
MFIEAGO:0046872metal ion binding
CCIBAGO:0022627cytosolic small ribosomal subunit
BPIBAGO:0000028ribosomal small subunit assembly
BPIDAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BPIMPGO:0031571mitotic G1 DNA damage checkpoint
BPIDAGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIDAGO:0045727positive regulation of translation

Gene expression in normal tissue: RPS27L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS27L

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-192823Viral mRNA Translation
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-2408557Selenocysteine synthesis
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72649Translation initiation complex formation
reactomeR-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
reactomeR-HSA-72689Formation of a pool of free 40S subunits
reactomeR-HSA-72695Formation of the ternary complex, and subsequently, the 43S complex
reactomeR-HSA-72702Ribosomal scanning and start codon recognition
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72764Eukaryotic Translation Termination
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
kegghsa03010Ribosome - Homo sapiens (human)
pidp53downstreampathwayDirect p53 effectors

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS27L