RPSA
Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ribosomal protein SA | MIM:150370 | Ensembl:ENSG00000168028 | HGNC:HGNC:6502 | PA30287 | 3p22.1 |
GO terms in RPSA
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0001618 | virus receptor activity |
MF | HDA | GO:0003723 | RNA binding |
MF | IBA | GO:0003735 | structural constituent of ribosome |
MF | IEA | GO:0005055 | laminin receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0043022 | ribosome binding |
BP | IBA | GO:0000028 | ribosomal small subunit assembly |
BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
BP | IBA | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
BP | IBA | GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
BP | IBA | GO:0006407 | rRNA export from nucleus |
BP | IBA | GO:0006412 | translation |
BP | IC | GO:0006412 | translation |
BP | TAS | GO:0006413 | translational initiation |
BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
BP | NAS | GO:0007155 | cell adhesion |
BP | IEA | GO:0046718 | viral entry into host cell |
CC | TAS | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
CC | HDA | GO:0016020 | membrane |
CC | IBA | GO:0022627 | cytosolic small ribosomal subunit |
CC | IDA | GO:0022627 | cytosolic small ribosomal subunit |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RPSA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPSA
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa03010 | Ribosome - Homo sapiens (human) |
netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
reactome | R-HSA-156902 | Peptide chain elongation |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-168254 | Influenza Infection |
reactome | R-HSA-168255 | Influenza Life Cycle |
reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-192823 | Viral mRNA Translation |
reactome | R-HSA-2408522 | Selenoamino acid metabolism |
reactome | R-HSA-2408557 | Selenocysteine synthesis |
reactome | R-HSA-376176 | Signaling by ROBO receptors |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-5663205 | Infectious disease |
reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
reactome | R-HSA-72312 | rRNA processing |
reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
reactome | R-HSA-72649 | Translation initiation complex formation |
reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
reactome | R-HSA-72764 | Eukaryotic Translation Termination |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
reactome | R-HSA-8953854 | Metabolism of RNA |
reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
biocarta | prionpathway | prion pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPSA