RRM2


Summary: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribonucleotide reductase regulatory subunit M2MIM:180390Ensembl:ENSG00000171848HGNC:HGNC:10452PA2992p25.1

Gene Categories:

DRUGGABLE GENOME

GO terms in RRM2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIEAGO:0006260DNA replication
BPIBAGO:0009263deoxyribonucleotide biosynthetic process
BPISSGO:0009263deoxyribonucleotide biosynthetic process
BPIEAGO:0055114oxidation-reduction process
BPTASGO:0070317negative regulation of G0 to G1 transition
MFIBAGO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
MFISSGO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
MFNASGO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: RRM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RRM2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-499943Interconversion of nucleotide di- and triphosphates
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953750Transcriptional Regulation by E2F6
pide2f_pathwayE2F transcription factor network
pharmgkbPA150653776Fluoropyrimidine Pathway, Pharmacokinetics
pharmgkbPA2036Gemcitabine Pathway, Pharmacodynamics
humancycPWY-7184pyrimidine deoxyribonucleotides de novo biosynthesis
humancycPWY-7210pyrimidine deoxyribonucleotides biosynthesis from CTP
humancycPWY-7211superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
humancycPWY-7226guanosine deoxyribonucleotides de novo biosynthesis
humancycPWY-7227adenosine deoxyribonucleotides de novo biosynthesis
humancycPWY-7228guanosine nucleotides de novo biosynthesis
humancycPWY-841purine nucleotides de novo biosynthesis
humancycPWY66-409superpathway of purine nucleotide salvage
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa00480Glutathione metabolism - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
smpdbSMP00046Pyrimidine Metabolism
smpdbSMP00050Purine Metabolism
smpdbSMP00144Adenosine Deaminase Deficiency
smpdbSMP00167Adenylosuccinate Lyase Deficiency
smpdbSMP00168AICA-Ribosiduria
smpdbSMP00172Beta Ureidopropionase Deficiency
smpdbSMP00178Dihydropyrimidinase Deficiency
smpdbSMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdbSMP00203Molybdenum Cofactor Deficiency
smpdbSMP00210Purine Nucleoside Phosphorylase Deficiency
smpdbSMP00219UMP Synthase Deiciency (Orotic Aciduria)
smpdbSMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdbSMP00364Lesch-Nyhan Syndrome (LNS)
smpdbSMP00365Gout or Kelley-Seegmiller Syndrome
smpdbSMP00427Azathioprine Action Pathway
smpdbSMP00428Mercaptopurine Action Pathway
smpdbSMP00430Thioguanine Action Pathway
smpdbSMP00446Gemcitabine Action Pathway
smpdbSMP00512Xanthinuria type I
smpdbSMP00513Xanthinuria type II
smpdbSMP00535Adenine phosphoribosyltransferase deficiency (APRT)
smpdbSMP00536Mitochondrial DNA depletion syndrome
smpdbSMP00537Myoadenylate deaminase deficiency
smpdbSMP00603Gemcitabine Metabolism Pathway
wikipathwaysWP1601Fluoropyrimidine Activity
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP4022Pyrimidine metabolism
wikipathwaysWP404Nucleotide Metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD79Gemcitabine1
iGMDRD517172249271

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RRM2

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