RTN2
Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| reticulon 2 | MIM:603183 | Ensembl:ENSG00000125744 | HGNC:HGNC:10468 | PA34881 | 19q13.32 |
GO terms in RTN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0014802 | terminal cisterna |
| CC | NAS | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | IEA | GO:0030315 | T-tubule |
| BP | IEA | GO:0046324 | regulation of glucose import |
| BP | IEA | GO:0065002 | intracellular protein transmembrane transport |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RTN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RTN2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RTN2
CLASSFICATION
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