S100A4
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| S100 calcium binding protein A4 | MIM:114210 | Ensembl:ENSG00000196154 | HGNC:HGNC:10494 | PA34906 | 1q21.3 |
GO terms in S100A4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0003779 | actin binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046914 | transition metal ion binding |
| MF | IEA | GO:0048306 | calcium-dependent protein binding |
| MF | IPI | GO:0050786 | RAGE receptor binding |
| CC | HDA | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0001837 | epithelial to mesenchymal transition |
| BP | IDA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
Gene expression in normal tissue: S100A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100A4
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