Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

S100 calcium binding protein A4MIM:114210Ensembl:ENSG00000196154HGNC:HGNC:10494PA349061q21.3

GO terms in S100A4

Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIEAGO:0003779actin binding
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046914transition metal ion binding
MFIEAGO:0048306calcium-dependent protein binding
MFIPIGO:0050786RAGE receptor binding
CCHDAGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIEAGO:0043005neuron projection
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
BPTASGO:0001837epithelial to mesenchymal transition
BPIDAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling

Gene expression in normal tissue: S100A4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in S100A4

DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in S100A4