SEC31A
Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SEC31 homolog A, COPII coat complex component | MIM:610257 | Ensembl:ENSG00000138674 | HGNC:HGNC:17052 | PA162402737 | 4q21.22 |
GO terms in SEC31A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0048306 | calcium-dependent protein binding |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | IDA | GO:0030120 | vesicle coat |
| CC | IBA | GO:0030127 | COPII vesicle coat |
| CC | IDA | GO:0030127 | COPII vesicle coat |
| CC | NAS | GO:0030127 | COPII vesicle coat |
| CC | IDA | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IBA | GO:0070971 | endoplasmic reticulum exit site |
| CC | IMP | GO:0070971 | endoplasmic reticulum exit site |
| BP | TAS | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | NAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IBA | GO:0007029 | endoplasmic reticulum organization |
| BP | IEA | GO:0015031 | protein transport |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | IDA | GO:0051592 | response to calcium ion |
| BP | IBA | GO:0090110 | cargo loading into COPII-coated vesicle |
| BP | IDA | GO:0090110 | cargo loading into COPII-coated vesicle |
| BP | IBA | GO:0090114 | COPII-coated vesicle budding |
Gene expression in normal tissue: SEC31A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEC31A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEC31A
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