SELENOV


Summary: This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
selenoprotein VMIM:607919Ensembl:ENSG00000186838HGNC:HGNC:3039919q13.2

GO terms in SELENOV


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0010269response to selenium ion
CCIBAGO:0005829cytosol
MFIPIGO:0005515protein binding

Gene expression in normal tissue: SELENOV

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SELENOV


DatabasePathway IDPathway Des.
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP28Selenium Metabolism and Selenoproteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SELENOV

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