SEMA4D
Summary:
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
semaphorin 4D | MIM:601866 | Ensembl:ENSG00000187764 | HGNC:HGNC:10732 | PA35654 | 9q22.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SEMA4D
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IMP | GO:0004888 | transmembrane signaling receptor activity |
MF | IDA | GO:0005102 | signaling receptor binding |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0030215 | semaphorin receptor binding |
MF | IPI | GO:0030215 | semaphorin receptor binding |
MF | ISS | GO:0030215 | semaphorin receptor binding |
MF | IDA | GO:0038023 | signaling receptor activity |
MF | IBA | GO:0038191 | neuropilin binding |
MF | IBA | GO:0045499 | chemorepellent activity |
BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IBA | GO:0001755 | neural crest cell migration |
BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
BP | TAS | GO:0006955 | immune response |
BP | TAS | GO:0007155 | cell adhesion |
BP | IDA | GO:0007162 | negative regulation of cell adhesion |
BP | IMP | GO:0008360 | regulation of cell shape |
BP | IMP | GO:0010693 | negative regulation of alkaline phosphatase activity |
BP | IMP | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
BP | IBA | GO:0030335 | positive regulation of cell migration |
BP | IDA | GO:0030335 | positive regulation of cell migration |
BP | ISS | GO:0030335 | positive regulation of cell migration |
BP | IMP | GO:0031344 | regulation of cell projection organization |
BP | TAS | GO:0043066 | negative regulation of apoptotic process |
BP | IMP | GO:0043547 | positive regulation of GTPase activity |
BP | ISS | GO:0043547 | positive regulation of GTPase activity |
BP | IMP | GO:0043931 | ossification involved in bone maturation |
BP | ISS | GO:0045668 | negative regulation of osteoblast differentiation |
BP | IMP | GO:0048672 | positive regulation of collateral sprouting |
BP | IMP | GO:0048814 | regulation of dendrite morphogenesis |
BP | IBA | GO:0048843 | negative regulation of axon extension involved in axon guidance |
BP | ISS | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
BP | ISS | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
BP | IBA | GO:0050919 | negative chemotaxis |
BP | IMP | GO:0070486 | leukocyte aggregation |
BP | IBA | GO:0071526 | semaphorin-plexin signaling pathway |
BP | IDA | GO:0071526 | semaphorin-plexin signaling pathway |
BP | IMP | GO:0071526 | semaphorin-plexin signaling pathway |
BP | ISS | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis |
CC | IBA | GO:0005615 | extracellular space |
CC | ISS | GO:0005615 | extracellular space |
CC | TAS | GO:0005886 | plasma membrane |
CC | IBA | GO:0005887 | integral component of plasma membrane |
CC | IDA | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: SEMA4D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEMA4D
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-373755 | Semaphorin interactions |
reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
reactome | R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration |
reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
reactome | R-HSA-416700 | Other semaphorin interactions |
reactome | R-HSA-422475 | Axon guidance |
kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEMA4D