SEMA6A


Summary: The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
semaphorin 6AMIM:605885Ensembl:ENSG00000092421HGNC:HGNC:10738PA356605q23.1

GO terms in SEMA6A


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0030215semaphorin receptor binding
MFIBAGO:0045499chemorepellent activity
BPIBAGO:0001755neural crest cell migration
BPNASGO:0006915apoptotic process
BPNASGO:0007010cytoskeleton organization
BPNASGO:0007166cell surface receptor signaling pathway
BPNASGO:0007399nervous system development
BPNASGO:0007411axon guidance
BPNASGO:0009887animal organ morphogenesis
BPIGIGO:0016525negative regulation of angiogenesis
BPIBAGO:0030335positive regulation of cell migration
BPIDAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIBAGO:0048843negative regulation of axon extension involved in axon guidance
BPIBAGO:0050919negative chemotaxis
BPIDAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIBAGO:0071526semaphorin-plexin signaling pathway
BPIGIGO:0106089negative regulation of cell adhesion involved in sprouting angiogenesis
BPIDAGO:1900747negative regulation of vascular endothelial growth factor signaling pathway
BPIDAGO:1903671negative regulation of sprouting angiogenesis
BPIBAGO:2001224positive regulation of neuron migration
CCIBAGO:0005615extracellular space
CCIBAGO:0005887integral component of plasma membrane
CCNASGO:0016021integral component of membrane
CCNASGO:0030424axon

Gene expression in normal tissue: SEMA6A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEMA6A


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-416700Other semaphorin interactions
reactomeR-HSA-422475Axon guidance
wikipathwaysWP2431Spinal Cord Injury
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEMA6A

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