SEMA6A
Summary: The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
semaphorin 6A | MIM:605885 | Ensembl:ENSG00000092421 | HGNC:HGNC:10738 | PA35660 | 5q23.1 |
GO terms in SEMA6A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0030215 | semaphorin receptor binding |
MF | IBA | GO:0045499 | chemorepellent activity |
BP | IBA | GO:0001755 | neural crest cell migration |
BP | NAS | GO:0006915 | apoptotic process |
BP | NAS | GO:0007010 | cytoskeleton organization |
BP | NAS | GO:0007166 | cell surface receptor signaling pathway |
BP | NAS | GO:0007399 | nervous system development |
BP | NAS | GO:0007411 | axon guidance |
BP | NAS | GO:0009887 | animal organ morphogenesis |
BP | IGI | GO:0016525 | negative regulation of angiogenesis |
BP | IBA | GO:0030335 | positive regulation of cell migration |
BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
BP | IBA | GO:0048843 | negative regulation of axon extension involved in axon guidance |
BP | IBA | GO:0050919 | negative chemotaxis |
BP | IDA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
BP | IBA | GO:0071526 | semaphorin-plexin signaling pathway |
BP | IGI | GO:0106089 | negative regulation of cell adhesion involved in sprouting angiogenesis |
BP | IDA | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
BP | IDA | GO:1903671 | negative regulation of sprouting angiogenesis |
BP | IBA | GO:2001224 | positive regulation of neuron migration |
CC | IBA | GO:0005615 | extracellular space |
CC | IBA | GO:0005887 | integral component of plasma membrane |
CC | NAS | GO:0016021 | integral component of membrane |
CC | NAS | GO:0030424 | axon |
Gene expression in normal tissue: SEMA6A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEMA6A
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-373755 | Semaphorin interactions |
reactome | R-HSA-416700 | Other semaphorin interactions |
reactome | R-HSA-422475 | Axon guidance |
wikipathways | WP2431 | Spinal Cord Injury |
kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEMA6A