SENP1
Summary: This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SUMO specific peptidase 1 | MIM:612157 | Ensembl:ENSG00000079387 | HGNC:HGNC:17927 | PA134947038 | 12q13.11 |
GO terms in SENP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | TAS | GO:0006508 | proteolysis |
| BP | IMP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0010724 | regulation of definitive erythrocyte differentiation |
| BP | TAS | GO:0016925 | protein sumoylation |
| BP | IBA | GO:0016926 | protein desumoylation |
| BP | IMP | GO:0016926 | protein desumoylation |
| BP | IEA | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0097190 | apoptotic signaling pathway |
| MF | TAS | GO:0004175 | endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | EXP | GO:0070139 | SUMO-specific endopeptidase activity |
| MF | ISS | GO:0070140 | SUMO-specific isopeptidase activity |
Gene expression in normal tissue: SENP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SENP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3065679 | SUMO is proteolytically processed |
| reactome | R-HSA-3215018 | Processing and activation of SUMO |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SENP1
CLASSFICATION
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