SENP2


Summary: SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SUMO specific peptidase 2MIM:608261Ensembl:ENSG00000163904HGNC:HGNC:23116PA1349551853q27.2

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in SENP2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0007507heart development
BPIEAGO:0009950dorsal/ventral axis specification
BPIEAGO:0015031protein transport
BPIEAGO:0016055Wnt signaling pathway
BPTASGO:0016925protein sumoylation
BPIBAGO:0016926protein desumoylation
BPIDAGO:0016926protein desumoylation
BPIMPGO:0016926protein desumoylation
BPNASGO:0030111regulation of Wnt signaling pathway
BPIDAGO:0031397negative regulation of protein ubiquitination
BPIMPGO:0031398positive regulation of protein ubiquitination
BPIMPGO:0031648protein destabilization
BPIEAGO:0032091negative regulation of protein binding
BPIEAGO:0032875regulation of DNA endoreduplication
BPIEAGO:0035562negative regulation of chromatin binding
BPIEAGO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator
BPISSGO:0045444fat cell differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051028mRNA transport
BPIEAGO:0060707trophoblast giant cell differentiation
BPIEAGO:0060711labyrinthine layer development
BPIEAGO:0060712spongiotrophoblast layer development
BPIEAGO:2000045regulation of G1/S transition of mitotic cell cycle
CCIBAGO:0005634nucleus
CCIDAGO:0005643nuclear pore
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCISSGO:0016605PML body
CCIEAGO:0031410cytoplasmic vesicle
CCIEAGO:0031965nuclear membrane
MFIPIGO:0005515protein binding
MFIEAGO:0019904protein domain specific binding
MFEXPGO:0070139SUMO-specific endopeptidase activity
MFIDAGO:0070139SUMO-specific endopeptidase activity
MFIEAGO:0070140SUMO-specific isopeptidase activity

Gene expression in normal tissue: SENP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SENP2


DatabasePathway IDPathway Des.
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3065679SUMO is proteolytically processed
reactomeR-HSA-3215018Processing and activation of SUMO
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
wikipathwaysWP428Wnt Signaling Pathway
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SENP2

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