SENP5
Summary: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
SUMO specific peptidase 5 | MIM:612845 | Ensembl:ENSG00000119231 | HGNC:HGNC:28407 | PA134917083 | 3q29 |
GO terms in SENP5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0007049 | cell cycle |
BP | TAS | GO:0016925 | protein sumoylation |
BP | IBA | GO:0016926 | protein desumoylation |
BP | IEA | GO:0051301 | cell division |
CC | IBA | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IEA | GO:0005730 | nucleolus |
MF | IPI | GO:0005515 | protein binding |
MF | EXP | GO:0070139 | SUMO-specific endopeptidase activity |
Gene expression in normal tissue: SENP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SENP5
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-2990846 | SUMOylation |
reactome | R-HSA-3065679 | SUMO is proteolytically processed |
reactome | R-HSA-3215018 | Processing and activation of SUMO |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in SENP5