SEPHS1
Summary: This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
selenophosphate synthetase 1 | MIM:600902 | Ensembl:ENSG00000086475 | HGNC:HGNC:19685 | PA134905215 | 10p13 |
Gene Categories:
KINASEGO terms in SEPHS1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0001887 | selenium compound metabolic process |
BP | TAS | GO:0006464 | cellular protein modification process |
BP | IBA | GO:0016260 | selenocysteine biosynthetic process |
BP | IEA | GO:0016260 | selenocysteine biosynthetic process |
BP | IEA | GO:0016310 | phosphorylation |
BP | IBA | GO:0070329 | tRNA seleno-modification |
CC | IBA | GO:0005737 | cytoplasm |
CC | IEA | GO:0005737 | cytoplasm |
CC | IEA | GO:0005886 | plasma membrane |
CC | IEA | GO:0031965 | nuclear membrane |
MF | IBA | GO:0004756 | selenide, water dikinase activity |
MF | IEA | GO:0004756 | selenide, water dikinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | TAS | GO:0005525 | GTP binding |
MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: SEPHS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEPHS1
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00450 | Selenocompound metabolism - Homo sapiens (human) |
humancyc | PWY-6281 | selenocysteine biosynthesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEPHS1