SGK1
Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serum/glucocorticoid regulated kinase 1 | MIM:602958 | Ensembl:ENSG00000118515 | HGNC:HGNC:10810 | PA162403013 | 6q23.2 |
GO terms in SGK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006814 | sodium ion transport |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0007616 | long-term memory |
| BP | TAS | GO:0008217 | regulation of blood pressure |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030334 | regulation of cell migration |
| BP | TAS | GO:0032411 | positive regulation of transporter activity |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0042127 | regulation of cell proliferation |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | TAS | GO:0050790 | regulation of catalytic activity |
| BP | TAS | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0060453 | regulation of gastric acid secretion |
| BP | TAS | GO:0070294 | renal sodium ion absorption |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | TAS | GO:0005246 | calcium channel regulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0015459 | potassium channel regulator activity |
| MF | TAS | GO:0015459 | potassium channel regulator activity |
| MF | TAS | GO:0017080 | sodium channel regulator activity |
| MF | TAS | GO:0017081 | chloride channel regulator activity |
Gene expression in normal tissue: SGK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SGK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| pid | foxopathway | FoxO family signaling |
| pid | insulin_pathway | Insulin Pathway |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL6 | IL6 |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD599 | Salermide | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD727 | Alpelisib | 2 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD85 | Ursolic acid | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD1004 | SGK1 inhibitor | 1 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD322 | FK 866 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SGK1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.