SH3KBP1


Summary: This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SH3 domain containing kinase binding protein 1MIM:300374Ensembl:ENSG00000147010HGNC:HGNC:13867PA37822Xp22.12

GO terms in SH3KBP1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006897endocytosis
BPIEAGO:0006915apoptotic process
BPIMPGO:0007010cytoskeleton organization
BPNASGO:0007267cell-cell signaling
BPTASGO:0007411axon guidance
BPIMPGO:0008360regulation of cell shape
BPIMPGO:0016477cell migration
BPTASGO:0042059negative regulation of epidermal growth factor receptor signaling pathway
BPTASGO:0061024membrane organization
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCTASGO:0005886plasma membrane
CCIEAGO:0005911cell-cell junction
CCIEAGO:0005925focal adhesion
CCISSGO:0030139endocytic vesicle
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIEAGO:0043005neuron projection
CCIEAGO:0045202synapse
MFIPIGO:0005515protein binding
MFIEAGO:0017124SH3 domain binding

Gene expression in normal tissue: SH3KBP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SH3KBP1


DatabasePathway IDPathway Des.
biocartacblpathwaycbl mediated ligand-induced downregulation of egf receptors pathway
biocartasprypathwaysprouty regulation of tyrosine kinase signals
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6807004Negative regulation of MET activity
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8866376Reelin signalling pathway
reactomeR-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cell
reactomeR-HSA-8876384Listeria monocytogenes entry into host cells
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
wikipathwaysWP437EGF-EGFR Signaling Pathway
piderbb1_internalization_pathwayInternalization of ErbB1
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
netpathPathway_EGFR1EGFR1
netpathPathway_KitReceptorKitReceptor
kegghsa04144Endocytosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SH3KBP1

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