SHC2


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SHC adaptor protein 2MIM:605217Ensembl:ENSG00000129946HGNC:HGNC:29869PA13497107619p13.3

GO terms in SHC2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPIEAGO:0000187activation of MAPK activity
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPTASGO:0007265Ras protein signal transduction
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
CCNDGO:0005575cellular_component
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIBAGO:0019901protein kinase binding
MFIBAGO:0030971receptor tyrosine kinase binding

Gene expression in normal tissue: SHC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SHC2


DatabasePathway IDPathway Des.
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pidvegfr1_pathwayVEGFR1 specific signals
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP481Insulin Signaling
wikipathwaysWP673ErbB Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SHC2

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