SHPRH
Summary: SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SNF2 histone linker PHD RING helicase | MIM:608048 | Ensembl:ENSG00000146414 | HGNC:HGNC:19336 | PA134880315 | 6q24.3 |
Gene Categories:
DNA REPAIRGO terms in SHPRH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0004386 | helicase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | EXP | GO:0061630 | ubiquitin protein ligase activity |
| CC | IEA | GO:0000786 | nucleosome |
| CC | TAS | GO:0005654 | nucleoplasm |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006334 | nucleosome assembly |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0016567 | protein ubiquitination |
Gene expression in normal tissue: SHPRH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SHPRH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SHPRH
CLASSFICATION
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