SIX2
Summary: This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
SIX homeobox 2 | MIM:604994 | Ensembl:ENSG00000170577 | HGNC:HGNC:10888 | PA35788 | 2p21 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in SIX2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | IBA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
MF | IEA | GO:0008134 | transcription factor binding |
MF | IEA | GO:0044877 | protein-containing complex binding |
BP | IBA | GO:0001822 | kidney development |
BP | IMP | GO:0001822 | kidney development |
BP | ISS | GO:0001822 | kidney development |
BP | IEA | GO:0002062 | chondrocyte differentiation |
BP | ISS | GO:0003337 | mesenchymal to epithelial transition involved in metanephros morphogenesis |
BP | IEA | GO:0006366 | transcription by RNA polymerase II |
BP | IEA | GO:0006606 | protein import into nucleus |
BP | ISS | GO:0007501 | mesodermal cell fate specification |
BP | IDA | GO:0008283 | cell proliferation |
BP | TAS | GO:0009653 | anatomical structure morphogenesis |
BP | ISS | GO:0009948 | anterior/posterior axis specification |
BP | IDA | GO:0016477 | cell migration |
BP | IEA | GO:0030278 | regulation of ossification |
BP | IEA | GO:0032330 | regulation of chondrocyte differentiation |
BP | IEA | GO:0042474 | middle ear morphogenesis |
BP | IEA | GO:0045596 | negative regulation of cell differentiation |
BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
BP | ISS | GO:0048557 | embryonic digestive tract morphogenesis |
BP | IEA | GO:0048701 | embryonic cranial skeleton morphogenesis |
BP | IBA | GO:0048856 | anatomical structure development |
BP | ISS | GO:0072006 | nephron development |
BP | ISS | GO:0072028 | nephron morphogenesis |
BP | ISS | GO:0072038 | mesenchymal stem cell maintenance involved in nephron morphogenesis |
BP | IEA | GO:0072137 | condensed mesenchymal cell proliferation |
BP | ISS | GO:0072161 | mesenchymal cell differentiation involved in kidney development |
BP | ISS | GO:0090189 | regulation of branching involved in ureteric bud morphogenesis |
BP | ISS | GO:0097168 | mesenchymal stem cell proliferation |
BP | ISS | GO:1902732 | positive regulation of chondrocyte proliferation |
CC | IBA | GO:0005634 | nucleus |
CC | IEA | GO:0005634 | nucleus |
CC | IBA | GO:0005667 | transcription factor complex |
Gene expression in normal tissue: SIX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIX2
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIX2