SIX2


Summary: This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SIX homeobox 2MIM:604994Ensembl:ENSG00000170577HGNC:HGNC:10888PA357882p21

GO terms in SIX2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIEAGO:0008134transcription factor binding
MFIEAGO:0044877protein-containing complex binding
BPIBAGO:0001822kidney development
BPIMPGO:0001822kidney development
BPISSGO:0001822kidney development
BPIEAGO:0002062chondrocyte differentiation
BPISSGO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0006606protein import into nucleus
BPISSGO:0007501mesodermal cell fate specification
BPIDAGO:0008283cell proliferation
BPTASGO:0009653anatomical structure morphogenesis
BPISSGO:0009948anterior/posterior axis specification
BPIDAGO:0016477cell migration
BPIEAGO:0030278regulation of ossification
BPIEAGO:0032330regulation of chondrocyte differentiation
BPIEAGO:0042474middle ear morphogenesis
BPIEAGO:0045596negative regulation of cell differentiation
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0048557embryonic digestive tract morphogenesis
BPIEAGO:0048701embryonic cranial skeleton morphogenesis
BPIBAGO:0048856anatomical structure development
BPISSGO:0072006nephron development
BPISSGO:0072028nephron morphogenesis
BPISSGO:0072038mesenchymal stem cell maintenance involved in nephron morphogenesis
BPIEAGO:0072137condensed mesenchymal cell proliferation
BPISSGO:0072161mesenchymal cell differentiation involved in kidney development
BPISSGO:0090189regulation of branching involved in ureteric bud morphogenesis
BPISSGO:0097168mesenchymal stem cell proliferation
BPISSGO:1902732positive regulation of chondrocyte proliferation
CCIBAGO:0005634nucleus
CCIEAGO:0005634nucleus
CCIBAGO:0005667transcription factor complex

Gene expression in normal tissue: SIX2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIX2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIX2

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