SIX6


Summary: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SIX homeobox 6MIM:606326Ensembl:ENSG00000184302HGNC:HGNC:10892PA3579214q23.1

GO terms in SIX6


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIEAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIEAGO:0003677DNA binding
CCIBAGO:0005634nucleus
CCIEAGO:0005634nucleus
CCIBAGO:0005667transcription factor complex
BPIBAGO:0001654eye development
BPIEAGO:0001654eye development
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0007601visual perception
BPTASGO:0009887animal organ morphogenesis
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0048856anatomical structure development

Gene expression in normal tissue: SIX6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIX6


DatabasePathway IDPathway Des.
wikipathwaysWP2858Ectoderm Differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIX6

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