SLC16A3
Summary: Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 16 member 3 | MIM:603877 | Ensembl:ENSG00000141526 | HGNC:HGNC:10924 | PA35815 | 17q25.3 |
GO terms in SLC16A3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006090 | pyruvate metabolic process |
| BP | IBA | GO:0015718 | monocarboxylic acid transport |
| BP | TAS | GO:0015718 | monocarboxylic acid transport |
| BP | IEA | GO:0035879 | plasma membrane lactate transport |
| BP | TAS | GO:0050900 | leukocyte migration |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008028 | monocarboxylic acid transmembrane transporter activity |
| MF | TAS | GO:0008028 | monocarboxylic acid transmembrane transporter activity |
| MF | EXP | GO:0015129 | lactate transmembrane transporter activity |
| MF | IEA | GO:0015293 | symporter activity |
Gene expression in normal tissue: SLC16A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC16A3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425366 | Transport of bile salts and organic acids, metal ions and amine compounds |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-433692 | Proton-coupled monocarboxylate transport |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC16A3
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