SLC16A5
Summary: This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 16 member 5 | MIM:603879 | Ensembl:ENSG00000170190 | HGNC:HGNC:10926 | PA35817 | 17q25.1 |
GO terms in SLC16A5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005215 | transporter activity |
| MF | IBA | GO:0008028 | monocarboxylic acid transmembrane transporter activity |
| MF | IEA | GO:0015293 | symporter activity |
| BP | IBA | GO:0015718 | monocarboxylic acid transport |
| BP | IEA | GO:0015718 | monocarboxylic acid transport |
| BP | IEA | GO:0055085 | transmembrane transport |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: SLC16A5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC16A5
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC16A5
CLASSFICATION
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