SLC1A5
Summary: The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
solute carrier family 1 member 5 | MIM:109190 | Ensembl:ENSG00000105281 | HGNC:HGNC:10943 | PA35830 | 19q13.32 |
Gene Categories:
TRANSPORTERGO terms in SLC1A5
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0001618 | virus receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | TAS | GO:0015171 | amino acid transmembrane transporter activity |
MF | TAS | GO:0015175 | neutral amino acid transmembrane transporter activity |
MF | TAS | GO:0015186 | L-glutamine transmembrane transporter activity |
MF | IEA | GO:0015194 | L-serine transmembrane transporter activity |
MF | IEA | GO:0015293 | symporter activity |
MF | TAS | GO:0038023 | signaling receptor activity |
BP | TAS | GO:0006865 | amino acid transport |
BP | TAS | GO:0006868 | glutamine transport |
BP | IEA | GO:0007165 | signal transduction |
BP | IEA | GO:0010585 | glutamine secretion |
BP | TAS | GO:0015804 | neutral amino acid transport |
BP | IEA | GO:0015825 | L-serine transport |
BP | IEA | GO:0046718 | viral entry into host cell |
BP | IEA | GO:1903803 | L-glutamine import across plasma membrane |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | HDA | GO:0016020 | membrane |
CC | IEA | GO:0042470 | melanosome |
CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: SLC1A5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC1A5
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
smpdb | SMP00001 | Citrullinemia Type I |
smpdb | SMP00002 | Carbamoyl Phosphate Synthetase Deficiency |
smpdb | SMP00003 | Argininosuccinic Aciduria |
smpdb | SMP00059 | Urea Cycle |
smpdb | SMP00205 | Ornithine Transcarbamylase Deficiency (OTC Deficiency) |
smpdb | SMP00357 | Argininemia |
smpdb | SMP00654 | Warburg Effect |
smpdb | SMP02298 | Glutaminolysis and Cancer |
wikipathways | WP3945 | TYROBP Causal Network |
wikipathways | WP3953 | mRNA, protein, and metabolite inducation pathway by cyclosporin A |
reactome | R-HSA-352230 | Amino acid transport across the plasma membrane |
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC1A5