SLC1A5


Summary: The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 1 member 5MIM:109190Ensembl:ENSG00000105281HGNC:HGNC:10943PA3583019q13.32

Gene Categories:

TRANSPORTER

GO terms in SLC1A5


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIPIGO:0005515protein binding
MFTASGO:0015171amino acid transmembrane transporter activity
MFTASGO:0015175neutral amino acid transmembrane transporter activity
MFTASGO:0015186L-glutamine transmembrane transporter activity
MFIEAGO:0015194L-serine transmembrane transporter activity
MFIEAGO:0015293symporter activity
MFTASGO:0038023signaling receptor activity
BPTASGO:0006865amino acid transport
BPTASGO:0006868glutamine transport
BPIEAGO:0007165signal transduction
BPIEAGO:0010585glutamine secretion
BPTASGO:0015804neutral amino acid transport
BPIEAGO:0015825L-serine transport
BPIEAGO:0046718viral entry into host cell
BPIEAGO:1903803L-glutamine import across plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0016020membrane
CCIEAGO:0042470melanosome
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: SLC1A5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC1A5


DatabasePathway IDPathway Des.
kegghsa04974Protein digestion and absorption - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
smpdbSMP00001Citrullinemia Type I
smpdbSMP00002Carbamoyl Phosphate Synthetase Deficiency
smpdbSMP00003Argininosuccinic Aciduria
smpdbSMP00059Urea Cycle
smpdbSMP00205Ornithine Transcarbamylase Deficiency (OTC Deficiency)
smpdbSMP00357Argininemia
smpdbSMP00654Warburg Effect
smpdbSMP02298Glutaminolysis and Cancer
wikipathwaysWP3945TYROBP Causal Network
wikipathwaysWP3953mRNA, protein, and metabolite inducation pathway by cyclosporin A
reactomeR-HSA-352230Amino acid transport across the plasma membrane
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD998Repligen-1361

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC1A5

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