SLC25A15


Summary: This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 25 member 15MIM:603861Ensembl:ENSG00000102743HGNC:HGNC:10985PA3586113q14.11

GO terms in SLC25A15


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0000064L-ornithine transmembrane transporter activity
MFIBAGO:0000064L-ornithine transmembrane transporter activity
MFIBAGO:0005476carnitine:acyl carnitine antiporter activity
MFIBAGO:0015226carnitine transmembrane transporter activity
BPTASGO:0000050urea cycle
BPIBAGO:0015879carnitine transport
BPTASGO:1990575mitochondrial L-ornithine transmembrane transport
CCTASGO:0005743mitochondrial inner membrane

Gene expression in normal tissue: SLC25A15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC25A15


DatabasePathway IDPathway Des.
smpdbSMP00001Citrullinemia Type I
smpdbSMP00002Carbamoyl Phosphate Synthetase Deficiency
smpdbSMP00003Argininosuccinic Aciduria
smpdbSMP00020Arginine and Proline Metabolism
smpdbSMP00059Urea Cycle
smpdbSMP00188Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
smpdbSMP00205Ornithine Transcarbamylase Deficiency (OTC Deficiency)
smpdbSMP00207Prolidase Deficiency (PD)
smpdbSMP00208Prolinemia Type II
smpdbSMP00357Argininemia
smpdbSMP00360Hyperprolinemia Type II
smpdbSMP00361Hyperprolinemia Type I
smpdbSMP00362Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
smpdbSMP00363Ornithine Aminotransferase Deficiency (OAT Deficiency)
smpdbSMP00504Creatine deficiency, guanidinoacetate methyltransferase deficiency
smpdbSMP00505Hyperornithinemia with gyrate atrophy (HOGA)
smpdbSMP00506Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
smpdbSMP00507L-arginine:glycine amidinotransferase deficiency
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-351202Metabolism of polyamines
reactomeR-HSA-70635Urea cycle
reactomeR-HSA-71291Metabolism of amino acids and derivatives

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC25A15

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