SLC29A4
Summary: This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 29 member 4 | MIM:609149 | Ensembl:ENSG00000164638 | HGNC:HGNC:23097 | PA134976472 | 7p22.1 |
Gene Categories:
TRANSPORTERGO terms in SLC29A4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005337 | nucleoside transmembrane transporter activity |
| MF | TAS | GO:0005337 | nucleoside transmembrane transporter activity |
| MF | IBA | GO:0008504 | monoamine transmembrane transporter activity |
| MF | IEA | GO:0008504 | monoamine transmembrane transporter activity |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| BP | IEA | GO:0015844 | monoamine transport |
| BP | IEA | GO:1901642 | nucleoside transmembrane transport |
Gene expression in normal tissue: SLC29A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC29A4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165948259 | Metformin Pathway, Pharmacokinetics |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC29A4
CLASSFICATION
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