SLC29A4
Summary: This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:609149 Ensembl IDEnsembl:ENSG00000164638 HGNC IDHGNC:HGNC:23097 PHARMGKB IDPA134976472 Map Location7p22.1 |
Gene Categories:
TRANSPORTERGO terms in SLC29A4
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0005337 | nucleoside transmembrane transporter activity |
MF | TAS | GO:0005337 | nucleoside transmembrane transporter activity |
MF | IBA | GO:0008504 | monoamine transmembrane transporter activity |
MF | IEA | GO:0008504 | monoamine transmembrane transporter activity |
CC | IBA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: SLC29A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC29A4
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Database | Pathway ID | Pathway Des. |
---|---|---|
pharmgkb | PA165948259 | Metformin Pathway, Pharmacokinetics |
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
reactome | R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC29A4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |