SLC4A8
Summary: The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 4 member 8 | MIM:605024 | Ensembl:ENSG00000050438 | HGNC:HGNC:11034 | PA35900 | 12q13.13 |
GO terms in SLC4A8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0032809 | neuronal cell body membrane |
| CC | IEA | GO:0043005 | neuron projection |
| BP | IEA | GO:0006814 | sodium ion transport |
| BP | IEA | GO:0015698 | inorganic anion transport |
| BP | IBA | GO:0015701 | bicarbonate transport |
| BP | TAS | GO:0015701 | bicarbonate transport |
| BP | IBA | GO:0051453 | regulation of intracellular pH |
| BP | IEA | GO:0098656 | anion transmembrane transport |
| MF | TAS | GO:0005452 | inorganic anion exchanger activity |
| MF | IBA | GO:0008509 | anion transmembrane transporter activity |
| MF | IBA | GO:0008510 | sodium:bicarbonate symporter activity |
| MF | IEA | GO:0015301 | anion:anion antiporter activity |
Gene expression in normal tissue: SLC4A8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC4A8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425381 | Bicarbonate transporters |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC4A8
CLASSFICATION
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