SLC4A8


Summary: The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier family 4 member 8MIM:605024Ensembl:ENSG00000050438HGNC:HGNC:11034PA3590012q13.13

GO terms in SLC4A8


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0032809neuronal cell body membrane
CCIEAGO:0043005neuron projection
BPIEAGO:0006814sodium ion transport
BPIEAGO:0015698inorganic anion transport
BPIBAGO:0015701bicarbonate transport
BPTASGO:0015701bicarbonate transport
BPIBAGO:0051453regulation of intracellular pH
BPIEAGO:0098656anion transmembrane transport
MFTASGO:0005452inorganic anion exchanger activity
MFIBAGO:0008509anion transmembrane transporter activity
MFIBAGO:0008510sodium:bicarbonate symporter activity
MFIEAGO:0015301anion:anion antiporter activity

Gene expression in normal tissue: SLC4A8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC4A8


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425381Bicarbonate transporters
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC4A8

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