Summary: This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015].

solute carrier family 5 member 2MIM:182381Ensembl:ENSG00000140675HGNC:HGNC:11037PA3590216p11.2

GO terms in SLC5A2

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0005975carbohydrate metabolic process
BPIBAGO:0006814sodium ion transport
BPIEAGO:0006814sodium ion transport
BPTASGO:0008645hexose transmembrane transport
BPIEAGO:1904659glucose transmembrane transport
CCTASGO:0005886plasma membrane
CCTASGO:0016021integral component of membrane
CCHDAGO:0070062extracellular exosome
MFTASGO:0005362low-affinity glucose:sodium symporter activity
MFEXPGO:0005412glucose:sodium symporter activity
MFIBAGO:0005412glucose:sodium symporter activity
MFTASGO:0005412glucose:sodium symporter activity

Gene expression in normal tissue: SLC5A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC5A2

DatabasePathway IDPathway Des.
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
reactomeR-HSA-189200Cellular hexose transport
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-5619102SLC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5658208Defective SLC5A2 causes renal glucosuria (GLYS1)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC5A2