SLC7A11
Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 7 member 11 | MIM:607933 | Ensembl:ENSG00000151012 | HGNC:HGNC:11059 | PA35919 | 4q28.3 |
GO terms in SLC7A11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0003333 | amino acid transmembrane transport |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007420 | brain development |
| BP | IDA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0015813 | L-glutamate transmembrane transport |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0070306 | lens fiber cell differentiation |
| BP | IEA | GO:0070527 | platelet aggregation |
| CC | IEA | GO:0005791 | rough endoplasmic reticulum |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0016021 | integral component of membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015179 | L-amino acid transmembrane transporter activity |
| MF | TAS | GO:0015327 | cystine:glutamate antiporter activity |
Gene expression in normal tissue: SLC7A11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC7A11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
| reactome | R-HSA-352230 | Amino acid transport across the plasma membrane |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP3953 | mRNA, protein, and metabolite inducation pathway by cyclosporin A |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC7A11
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