SLCO1B3
Summary: This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier organic anion transporter family member 1B3 | MIM:605495 | Ensembl:ENSG00000111700 | HGNC:HGNC:10961 | PA35844 | 12p12.2 |
GO terms in SLCO1B3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| BP | TAS | GO:0015711 | organic anion transport |
| BP | IBA | GO:0015721 | bile acid and bile salt transport |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | IBA | GO:0043252 | sodium-independent organic anion transport |
| BP | TAS | GO:0043252 | sodium-independent organic anion transport |
| BP | IEA | GO:0055085 | transmembrane transport |
| MF | TAS | GO:0008514 | organic anion transmembrane transporter activity |
| MF | IBA | GO:0015125 | bile acid transmembrane transporter activity |
| MF | TAS | GO:0015125 | bile acid transmembrane transporter activity |
| MF | IBA | GO:0015347 | sodium-independent organic anion transmembrane transporter activity |
Gene expression in normal tissue: SLCO1B3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLCO1B3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00434 | Paclitaxel Action Pathway |
| smpdb | SMP00435 | Docetaxel Action Pathway |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011109 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011110 | Pravastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011111 | Fluvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011112 | Rosuvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA166041114 | Ibuprofen Pathway, Pharmacokinetics |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5619058 | Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) |
| reactome | R-HSA-5619102 | SLC transporter disorders |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-879518 | Transport of organic anions |
| reactome | R-HSA-8957322 | Metabolism of steroids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLCO1B3
CLASSFICATION
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