SMARCA5
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | MIM:603375 | Ensembl:ENSG00000153147 | HGNC:HGNC:11101 | PA35951 | 4q31.21 |
GO terms in SMARCA5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000793 | condensed chromosome |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005677 | chromatin silencing complex |
| CC | IDA | GO:0016589 | NURF complex |
| CC | IPI | GO:0031213 | RSF complex |
| CC | IDA | GO:0043596 | nuclear replication fork |
| BP | IEA | GO:0000183 | chromatin silencing at rDNA |
| BP | IDA | GO:0006334 | nucleosome assembly |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IDA | GO:0006352 | DNA-templated transcription, initiation |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0016584 | nucleosome positioning |
| BP | TAS | GO:0034080 | CENP-A containing nucleosome assembly |
| BP | IMP | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | TAS | GO:0045815 | positive regulation of gene expression, epigenetic |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IEA | GO:0004386 | helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IEA | GO:0031491 | nucleosome binding |
| MF | IDA | GO:0042393 | histone binding |
Gene expression in normal tissue: SMARCA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMARCA5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250924 | B-WICH complex positively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| reactome | R-HSA-5693606 | DNA Double Strand Break Response |
| reactome | R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-774815 | Nucleosome assembly |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMARCA5
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